Basic concept - why aLeaves?
history of every gene in the human genome, as well as every gene that
before the establishment of the human genome, is traceable by
homologs of the gene of particular interest. This web server allows
researchers and even non-researchers to explore
protein-coding landscape of vertebrate genomes.
all sequence information produced thanks to recent rapid innovation of
sequencing technologies, typical work flow in which we handle the
sequence information tends to be out-dated. By starting with exhaustive
(but still not complete, of course) search of homologs, aLeaves
provides a solution to avoid any misidentification in interpretation
of molecular phylogeny (e.g., hidden paralogy).
About the developers
Shigehiro Kuraku - Unit Leader at Phyloinforamtics Unit,
for Life Science Technologies, RIKEN> in Kobe, Japan.
- Bioinformatician at Phyloinformatics
for Life Science Technologies, RIKEN in Kobe, Japan.
- Associate Professor, Osaka University in Osaka, Japan, and visiting
researcher at CBRC, AIST in Tokyo, Japan.
project is funded by RIKEN.
To cite aLeaves
The article introducing the aLeaves server has been
published in the Web
Server Issue 2013
of the journal Nucleic
facilitates on-demand exploration of metazoan gene family trees on
MAFFT sequence alignment server with enhanced interactivity.
Christian Zmasek, Osamu Nishimura, and Kazutaka Katoh.
Nucleic Acids Research,
2013. 41 (W1): W22-W28.
For further info, please contact the chief administrator,
Shigehiro Kuraku (shigehiro.kuraku